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However, antidepressant efficacy of SSRIs/SNRIs is lost over time in some patients, a phenomenon sometimes called trazodone uk desyrel nasil kullanilir molipaxin oral solution desyrel erowid trazodone side effects “poop-out . ” Hypothetically, unwanted desensitization of post synaptic 5-HT1A receptors could be linked to this loss desyrel off label uses desyrel bold font molipaxin ulotka desyrel prozac desyrel ve uyku trazodone of efficacy after long term drug administration .
Postsynaptic 5-HT2A and 5-HT2C desyrel ne demek trazodone zoloft wellbutrin trazodone can you overdose trazodone la thuoc gi receptors often desensitize as well in many patients after long term administration of SSRIs/SNRIs, hypothetically leading to abatement of some side effects linked to these receptors, especially anxiety (Figures 4B, 4C, and 5) .
Insomnia, on the other hand, is not as readily improved after long term treatment with SSRIs/SNRIs and in fact is the most common residual symptom after trazodone treatment with these agents . 9 Sexual dysfunction can wane with chronic administration of SSRIs/SNRIs but in many desyrel uses trittico youtube trittico effetti oleptro half life trazodone recall desyrel uyku ilacı patients is a persistent problem .
In summary, by raising serotonin at all serotonin receptors and in all brain areas, SERT inhibitors such as SSRIs and SNRIs simultaneously cause antidepressant trazodone actions by stimulating 5-HT 1A receptors, but side effects by stimulating 5-HT 2A and 5-HT 2C receptors (Figures 4 and 6) .
However, when SERT inhibition is combined with 5-HT2A/2C inhibition, this leads to antidepressant actions without trazodone sexual dysfunction, anxiety, or insomnia (Figure 7) .

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