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A large trileptal side effects bipolar trileptal and alcohol trileptal and alcohol trileptal mood swings number of open clinical trial were published, and considerable experience with the drug obtained .
A further clinical trial programme was embarked upon in the early 1990s, in order to comply with trileptal for sleep trileptal prescribing information trileptal headaches trileptal for depression GCP (Good Clinical Practice) guidelines and to allow the drug to be put forward for licens- ing in the USA, UK and more widely in Europe .
This trial programme has now been successfully completed, and the antiepileptic efficacy of the drug has been proven beyond question2, trileptal 3, 11, 18, 23, 24, 26, 27 .
Significant trileptal superiority of oxcarbazepine over placebo was demonstrated in the add-on trials in adults and children .
In adults, the median reduction in partial seizure frequency was between 26% (600 mg/day) trileptal reviews trileptal weight trileptal for depression anxiety trileptal during pregnancy and 40% (2400 mg/day), and the number of responders (>50% reduction in seizure frequency) was also significantly greater on 2400 mg than 600 mg/day (50% vs .
(Barcs et al, submitted to trileptal images trileptal and low sodium oxcarbazepine trileptal trileptal sleep trileptal for Epilepsia) .
Furthermore, oxcarbazepine trileptal has been tested in four randomized double-blind monotherapy trials, including one short-term study of patients being evaluated for epilepsy surgery29 , one study in new patients30 and two monotherapy substitution studies in refractory cases31, 32 .
All four studies trileptal demonstrated that a high dose of the drug was either superior to placebo or to a low dose29–32 .
An excellent feature of the trial programme is that comparative data was also obtained comparing oxcarbazepine to other established antiepileptic drugs (and trileptal not just placebo)18, 19, 22 .

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